| 名稱(chēng) | EZH2 p.Y646N Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10275 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | EZH2 p.Y646N Reference Standard |
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10275EZH2 p.Y646N Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
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CBP10275 | |
| Format | Genomic DNA |
| Description | EZH2 Y646N (also reported as Y641N) lies within a SET domain of the Ezh2 protein (UniProt.org). Y646N confers a gain of function to the Ezh2 protein, as demonstrated by increased trimethylation at H3K27 (PMID: 22194861) and promotion of tumor growth in cell line derived xenograft models (PMID: 25493630). |
| Technical Data | |
| DNA Change | c.1936T>A |
| AA Change | p.Y646N |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 50.00% |
| Transcript | ENST00000320356 |
| Cosmic ID | COSM37031 |
| Chr position(GRCh37) | chr7:148508728 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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