名稱 | BAFF CHO |
型號(hào) | CBP74286 |
報(bào)價(jià) | ![]() |
特點(diǎn) | BAFF CHO |
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藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74286BAFF CHO

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BAFF CHO BAFF CHO BAFF CHO
I. Background | |
BAFF(B 細(xì)胞激活因子,B Cell Activating Factor),也稱為 TNFSF13B(Tumor Necrosis Factor Superfamily Member 13B)或 BLyS(B Lymphocyte Stimulator),是一種屬 于腫瘤壞死因子(TNF)超家族的細(xì)胞因子。BAFF 主要由單核細(xì)胞、巨噬細(xì)胞、樹(shù)突狀 細(xì)胞和某些基質(zhì)細(xì)胞產(chǎn)生,在 B 細(xì)胞的存活、增殖和成熟中起關(guān)鍵作用。 BAFF 通過(guò)與受體結(jié)合,調(diào)節(jié) B 細(xì)胞的發(fā)育和功能,其過(guò)度表達(dá)與自身免疫性疾病 (如系統(tǒng)性紅斑狼瘡、類風(fēng)濕性關(guān)節(jié)炎)密切相關(guān)。BAFF 有三個(gè)主要受體:BAFF-R (BR3)、TACI 和 BCMA。BAFF 與 BAFF-R 結(jié)合后,激活 NF-κB 和 PI3K/AKT 通路,促 進(jìn) B 細(xì)胞的存活和增殖;TACI 介導(dǎo) BAFF 和 APRIL(另一種 TNF 家族成員)的信號(hào)傳導(dǎo), 調(diào)節(jié) B 細(xì)胞的活化和抗體產(chǎn)生;BCMA 主要在漿細(xì)胞中表達(dá),介導(dǎo) BAFF 和 APRIL 的信 號(hào)傳導(dǎo),支持漿細(xì)胞的存活。BAFF 的過(guò)度表達(dá)與系統(tǒng)性紅斑狼瘡(SLE)、類風(fēng)濕性關(guān)節(jié) 炎(RA)、干燥綜合等自身免疫性疾病密切相關(guān)。 | |
II. Description | |
BAFF CHO 細(xì)胞,在 CHO-K1 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)人 BAFF。 | |
III. Introduction | |
Expressed gene: | BAFF |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | F12K+10%FBS+600 μg/ml Hygromycin B |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Binding Assay,FACS |
IV. Representative Data Figure 1. Recombinant BAFF CHO stably expressing BAFF.
Figure 3. Blocking of BAFF induced BAFFR Effector Reporter Cell(C14) Activity by BAFFR Blocking Ab with BAFF CHO. Blocking of BAFF induced BAFFR Effector Reporter Cell(C14) Activity by BAFF Blocking Ab with BAFF CHO. |